Thermo Fisher Scientific CD7 Monoclonal Antibody (1B8)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
PGALAAQEVQ QSPHCTTVPV GASVNITCST SGGLRGIYLR QLGPQPQDII YYEDGVVPTT DRRFRGRIDF SGSQDNLTIT MHRLQLSDTG TYTCQAITEV NVYGSGTLVL VTEEQSQGWH RCSDAPPRAS ALPAPPTGSA LPDPQTASAL PDPPAASALP AALAVISFLL GLGLGVACVL ARTQIKKLCS WRDKNSAACV VYEDMSHSRC NTLSSPNQYQ

Target Information

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily.

• N-terminal amino acids (1–107) are highly homologous to Ig kappa-L chains.
• The carboxy-terminal region of the extracellular domain is proline-rich and may form a stalk projecting the Ig domain.
• Expressed on immature and mature T-lymphocytes, T cell leukemia, natural killer cells, a small subset of normal and malignant B cells.
• Cross-linking of surface CD7 modulates T cell and NK cell activity (calcium flux, adhesion molecule expression, cytokine secretion, proliferation).
• CD7 associates directly with phosphoinositol 3-kinase and induces D-3 phosphoinositide production and tyrosine phosphorylation.
• CD7 expression is an important marker in leukemia diagnostics.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.