Thermo Fisher Scientific EXOSC6 Polyclonal Antibody
Rabbit polyclonal antibody targeting human EXOSC6. Validated for WB and IHC-P applications. Recognizes RNA exosome complex component involved in RNA processing. Supplied as liquid, 1 mg/mL, Protein A purified, stored at -20°C. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 5.0 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of human EXOSC6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688361 |
Product Specific Information
This target displays homology in the following species:
- Cow: 93%
- Human: 100%
- Mouse: 88%
- Pig: 86%
- Rat: 93%
Target Information
EXOSC6 is a non-catalytic component of the RNA exosome complex, which exhibits 3’→5’ exoribonuclease activity. It participates in multiple RNA processing and degradation events in both the nucleus and cytoplasm.
In the nucleus, the RNA exosome complex:
- Matures stable RNA species such as rRNA, snRNA, and snoRNA
- Eliminates RNA processing by-products and pervasive non-coding transcripts (e.g., antisense RNA, PROMPTs)
- Degrades defective mRNAs to prevent their export to the cytoplasm
In the cytoplasm, it:
- Facilitates general mRNA turnover
- Degrades unstable mRNAs containing AU-rich elements (AREs)
- Participates in RNA surveillance pathways
- May contribute to histone mRNA degradation
The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) acts as a scaffold for RNA binding and presentation for ribonucleolysis, and for association with catalytic subunits and accessory proteins or complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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