Thermo Fisher Scientific Wilms Tumor Protein Polyclonal Antibody, Biotin
Wilms Tumor Protein(WT1)을 인식하는 Biotin 결합 폴리클로날 항체로, Western blot, ELISA, Immunoprecipitation에 적합합니다. Human, Mouse, Rat 반응성이 있으며, Rabbit IgG로 제작되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- WT1-BIOTIN
- 판매단위
- pk
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Thermo Fisher Scientific Wilms Tumor Protein Polyclonal Antibody, Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Wilms tumor protein WT1 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Wilms Tumor 1 gene encodes one of the WPP domain-interacting proteins (Wilms Tumor 1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells.
Ran GTPase is essential for nucleocytoplasmic transport, spindle formation, and nuclear envelope reassembly.
The cytoplasmic Ran GTPase activating protein RanGAP establishes a functional RanGTP/RanGDP gradient across the nuclear envelope and associates with its outer surface in metazoan and higher plant cells.
In Arabidopsis thaliana, RanGAP association with the root tip nuclear envelope requires plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs).
Wilms Tumor 1 and WIT2 are a second family of CC-TMD proteins, structurally similar but distinct from WIPs, required for RanGAP nuclear envelope association in root tip cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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