Thermo Fisher Scientific JMJD1C Polyclonal Antibody
Rabbit polyclonal antibody targeting human JMJD1C protein. Validated for ICC/IF applications. High specificity with recombinant human JMJD1C immunogen. Suitable for research use in epigenetic and transcriptional regulation studies. Supplied in liquid f...
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Applications
- Immunocytochemistry (ICC/IF)
Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human JMJD1C. Recombinant protein control fragment (Product #RP-107486) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663366 |
Product Specific Information
Immunogen sequence:
IIPGSVLTDLL DAMHTLREKY GIKSHCHCTN KQNLQVGNFP TMNGVSQVLQ NVLNHSNKIS LCMPESQQQN TPPKS
Highest antigen sequence identity to the following orthologs:
- Mouse: 86%
- Rat: 82%
Target Information
The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico and later suggested to be a candidate gene for autism. Like JMJD1A and JMJD1B, JMJD1C acts as a histone H3K9 demethylase involved in nuclear hormone receptor-based transcriptional regulation.
JMJD1C mRNA is highly expressed in undifferentiated embryonic stem (ES) cells, pancreatic islet, diffuse-type gastric cancer, and other tissues and tumors. Its gene promoter contains bHLH-, AP-1-, and POU5F1-binding sites. POU5F1-mediated expression of JMJD1C may reactivate previously silenced genes in ES cells and diffuse-type gastric cancer.
At least three isoforms of JMJD1C are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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