ELK Biotechnology RPGF2 rabbit pAb

제품명

RPGF2 rabbit pAb

제품 개요

RPGF2 단백질을 인식하는 토끼 유래 폴리클로날 항체입니다. Western Blot(WB) 및 ELISA 실험에 사용되며, RAPGEF2 단백질의 세포 내 위치 및 발현 연구에 적합합니다.

제품 정보

세포 내 위치

Cytoplasm, perinuclear region, cell membrane, late endosome, cell junction. Associated with the synaptic plasma membrane. Colocalizes with ADRB1 at the plasma membrane. Enriched in synaptic plasma membrane and neuronal cell body. Colocalized with CTNNB1 at cell-cell contacts (By similarity). Localized diffusely in the cytoplasm before neuronal growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with the high affinity nerve growth factor receptor NTRK1 at late endosomes. Translocated to the perinuclear region in a RAP1A-dependent manner. Translocated to the cell membrane.

배경(Background)

Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]). [Supplied by OMIM, Mar 2008]