ELK Biotechnology RFIP5 rabbit pAb
RFIP5 rabbit polyclonal antibody for WB and ELISA applications. Recognizes human protein derived peptide (AA 570–650). Cytoplasmic and membrane localization. Useful in studies of protein trafficking and autoimmune disease research.
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RFIP5 rabbit pAb
제품 개요
ELK Biotechnology에서 제공하는 RFIP5 rabbit polyclonal antibody는 인간 RFIP5 단백질 유래 합성 펩타이드(AA 570–650)를 면역원으로 제작되었습니다. 단백질 이동 및 재활용 엔도솜 관련 연구에 적합하며, SLE 및 SS 등 자가면역 질환 연구에도 활용 가능합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | RFIP5 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1:500–2000, ELISA: 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 570–650) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 71 kD |
| GeneID (Human) | 26056 |
| Human Swiss-Prot No | Q9BXF6 |
| Cellular Localization | Cytoplasm; Recycling endosome membrane; Peripheral membrane protein; Early endosome membrane; Golgi apparatus membrane; Cytoplasmic vesicle, secretory vesicle membrane; Mitochondrion membrane |
| Species Reactivity | Human; Mouse |
Background
Antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus (SLE) or Sjögren syndrome (SS), and in sera from mothers of children with neonatal lupus erythematosus (NLE).
Binds vesicles enriched in neutral phospholipids via its C2 domain, favored by Mg²⁺ rather than Ca²⁺.
Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane.
Phosphorylated on serine and threonine residues.
Contains one C2 domain.
Forms a heterooligomeric complex with RAB11FIP4. Binds NAPG, SSA2, and RAB11A (GTP-bound form).
Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle, and pancreas.
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