ELK Biotechnology KCNE3 rabbit pAb
KCNE3 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 사용 가능. 인간, 생쥐, 랫트 시료에 반응하며 세포막 및 세포질에 위치한 단백질 검출에 적합. 고농도(1 mg/ml)로 제공되며 -20°C에서 1년 보관 가능.
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KCNE3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | KCNE3 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 30–110) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 11 kD |
| GeneID (Human) | 10008 |
| Human Swiss-Prot No | Q9Y6H6 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cytoplasm; Perikaryon; Cell projection (dendrite); Membrane raft. Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal neurons. |
Background
Potassium voltage-gated channel subfamily E regulatory subunit 3 (KCNE3) is a member of the voltage-gated potassium (Kv) channel family, known for their structural and functional complexity. These channels regulate various physiological processes such as neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
KCNE3 encodes a type I membrane protein that acts as a beta subunit, assembling with potassium channel alpha-subunits to modulate gating kinetics and enhance stability of the multimeric complex. It is prominently expressed in the kidney, and mutations in this gene are associated with hypokalemic periodic paralysis.
[Provided by RefSeq, Jul 2008]
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