ELK Biotechnology AT2B2 rabbit pAb
AT2B2 rabbit polyclonal antibody for WB and ELISA applications. Targets human plasma membrane calcium ATPase isoform 2. Provides reliable detection of 136 kDa band. Suitable for human and rat samples. Long-term storage at −20 °C.
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AT2B2 Rabbit Polyclonal Antibody
Supplier: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | AT2B2 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 250–330) |
| Species Reactivity | Human; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 136 kDa |
| GeneID (Human) | 491 |
| Human Swiss-Prot No | Q01814 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein; Cell junction, synapse. Isoform WA: Apical cell membrane; Basolateral cell membrane. Isoform WB: Apical cell membrane; Basolateral cell membrane. Isoform XB: Basolateral cell membrane. Isoform ZA: Basolateral cell membrane. Isoform ZB: Basolateral cell membrane. |
| Storage | −20 °C (1 year) |
Background
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against large concentration gradients and play a critical role in intracellular calcium homeostasis. Mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes, and diversity is further increased by alternative splicing. Expression of different isoforms and splice variants is regulated in a developmental, tissue-, and cell type-specific manner, suggesting functional adaptation to physiological needs. This gene encodes the plasma membrane calcium ATPase isoform 2.
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