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ELK Biotechnology NPL4 rabbit pAb
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ELK Biotechnology NPL4 rabbit pAb

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NPL4 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 랫드, 마우스 시료에서 반응하며, 세포질 및 핵 내 NPL4 단백질 검출에 유용합니다. -20°C 보관 시 1년 안정합니다.

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ELK Biotechnology ES9944-100UL NPL4 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES9944-50UL NPL4 rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology NPL4 rabbit pAb

NPL4 rabbit pAb

제품 정보

항목 내용
Product name NPL4 rabbit pAb
Applications WB, ELISA
Recommended Dilutions WB: 1:500–2000, ELISA: 1:5000–20000
Immunogen Synthesized peptide derived from human protein (AA range: 270–350)
Host Rabbit
Storage -20°C / 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 66 kDa
Gene ID (Human) 55666
Human Swiss-Prot No. Q8TAT6
Cellular Localization Cytoplasm, cytosol, endoplasmic reticulum, nucleus (associated with ER and nuclear regions)
Species Reactivity Human, Rat, Mouse

Background

  • Domain: Binds ubiquitinated proteins via its RanBP2-type zinc finger.
  • Function: The ternary complex containing UFD1L, VCP, and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome.
  • Pathway: Protein degradation; proteasomal ubiquitin-dependent pathway.
  • Similarity: Belongs to the NPL4 family; contains one RanBP2-type zinc finger.
  • Subcellular location: Associated with the endoplasmic reticulum and nuclear regions.
  • Subunit: Forms a heterodimer with UFD1L, which binds ubiquitinated proteins and associates with VCP to inhibit Golgi membrane fusion.
  • Tissue specificity: Expressed at highest levels in brain, heart, skeletal muscle, kidney, and fetal liver.

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