
ELK Biotechnology NIPBL rabbit pAb
NIPBL 단백질을 인식하는 rabbit polyclonal 항체로, IHC 및 IF 분석에 적합합니다. 인간과 생쥐 시료에 반응하며 핵 및 염색체에 위치합니다. -20°C에서 1년 보관 가능하며 1 mg/ml 농도로 제공됩니다.
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제품명
NIPBL rabbit pAb
제품 개요
NIPBL 단백질을 인식하는 rabbit polyclonal 항체로, 인간 및 생쥐 시료에서 IHC 및 IF 분석에 사용됩니다. 본 항체는 핵과 염색체에 위치한 NIPBL 단백질을 검출할 수 있습니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Applications | IHC; IF |
| Recommended Dilutions | IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 560–640) |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 308 kD |
| GeneID (Human) | 25836 |
| Human Swiss-Prot No | Q6KC79 |
| Cellular Localization | Nucleus; Chromosome |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins, and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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