ELK Biotechnology UNC5D rabbit pAb
UNC5D 단백질을 인식하는 토끼 폴리클로날 항체로 WB 및 ELISA에 적합합니다. 인간 및 생쥐 시료에 반응하며, 세포막 단백질 검출에 유용합니다. 고순도 IgG 형태로 -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
UNC5D rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 160–240) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 104 kD |
| GeneID (Human) | 137970 |
| Human Swiss-Prot No | Q6UXZ4 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse |
| Storage | -20°C / 1 year |
Background
Function: Receptor for netrin, potentially involved in axon guidance by mediating axon repulsion of neuronal growth cones during nervous system development upon ligand binding. Axon repulsion may be triggered by association with DCC, inducing repulsion signaling.
Apoptosis: Acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Post-translational Modifications (PTM): Phosphorylated on cytoplasmic tyrosine residues; proteolytically cleaved by caspases during apoptosis (cleavage blocked when bound to netrin).
Similarity: Belongs to the unc-5 family; contains 1 death domain, 1 Ig-like domain, 1 Ig-like C2-type domain, 1 ZU5 domain, and 2 TSP type-1 domains.
Subunit: Interacts with the cytoplasmic part of DCC.
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