ELK Biotechnology MYO15 rabbit pAb
MYO15 단백질을 인식하는 토끼 폴리클로날 항체로, IHC 및 IF 실험에 적합합니다. 인간 및 생쥐 시료에서 반응하며, 세포 골격 및 스테레오실리움 내 위치 연구에 유용합니다. -20°C에서 1년간 보관 가능합니다.
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MYO15 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | IHC; IF |
| Recommended Dilutions | IHC-p 1:50–300 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 2990–3070) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 388 kD |
| Gene ID (Human) | 51168 |
| Human Swiss-Prot No. | Q9UKN7 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cell projection, stereocilium; Cytoplasm, cytoskeleton. Localizes to stereocilium tips in cochlear and vestibular hair cells. |
Background
This gene encodes an unconventional myosin that differs from other myosins by having a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified but are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full-length sequences have not been determined.
(Source: RefSeq, Jul 2008)
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