ELK Biotechnology MED28 rabbit pAb
MED28 rabbit polyclonal antibody for WB and ELISA applications. Recognizes human MED28 protein involved in transcription regulation. Suitable for human, mouse, and rat samples. High specificity and stable storage at -20°C for up to 1 year.
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제품명
MED28 rabbit pAb
적용 분야
- WB (Western Blot)
- ELISA
권장 희석 배율
- WB: 1:500–2000
- ELISA: 1:5000–20000
제품 정보
| 항목 | 내용 |
|---|---|
| Immunogen | Synthesized peptide derived from human protein (AA range: 20–100) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 19 kD |
| GeneID (Human) | 80306 |
| Human Swiss-Prot No | Q9H204 |
| Cellular Localization | Nucleus, Cytoplasm, Membrane; Peripheral membrane protein. According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated. |
| Species Reactivity | Human, Mouse, Rat |
Background
MED28 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. The Mediator functions as a bridge between gene-specific regulatory proteins and the basal RNA polymerase II transcription machinery. It is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for assembling a functional preinitiation complex.
MED28 may form part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.
It is up-regulated in endothelial cells exposed to tumor-conditioned media and belongs to the Mediator complex subunit 28 family.
Subunit Information:
Component of the Mediator complex composed of multiple subunits including MED1–MED31, CCNC, CDK8, and CDC2L6/CDK11. The MED12, MED13, CCNC, and CDK8 subunits form the CDK8 module, which reduces transcriptional activation compared to Mediator lacking this module.
Complex Associations:
Forms a ternary complex with NF2/merlin and GRB2, and binds to actin.
Tissue Specificity:
Widely expressed, highly in vascular tissues such as placenta, testis, and liver.
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