Thermo Fisher Scientific MASTL Polyclonal Antibody
MASTL 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체. IHC 및 파라핀 절편에서 사용 가능하며, 인간 시료에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 보관. 세포주기 및 암 연구에 적합.
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Thermo Fisher Scientific MASTL Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 550 and 600 of human microtubule associated serine/threonine kinase-like |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
MASTL (microtubule associated serine/threonine kinase-like) belongs to the MAST family, AGC Ser/Thr protein kinase group.
MASTL promotes mitotic progression and cell cycle reentry after DNA damage. Loss of MASTL leads to defects in chromosome condensation, separation, and other aspects of mitotic progression, primarily mediated by inhibiting PP2A/B55 delta.
Overexpression of MASTL is correlated with cancer progression, poor patient survival, and tumor recurrence in various cancers.
Mutations at this locus are associated with autosomal dominant thrombocytopenia (thrombocytopenia-2). Alternatively spliced transcript variants have been described for this locus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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