Thermo Fisher Scientific TWIST1 and TWIST2 Polyclonal Antibody
TWIST1 및 TWIST2 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체입니다. Western blot, IHC, ICC/IF, ELISA 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 단백질 A 정제, 고순도 액상 형태로 연구용 적합.
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Thermo Fisher Scientific TWIST1 and TWIST2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TWIST1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Twist1/Twist2 encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate transcription of genes involved in cranial suture closure during skull development. It may also regulate neural tube closure, limb development, and brown fat metabolism.
Twist1/Twist2 is hypermethylated and overexpressed in multiple human cancers, promoting tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome, characterized by craniosynostosis, ptosis, and hypertelorism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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