Thermo Fisher Scientific GSPT1 Polyclonal Antibody
Human GSPT1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제된 액상 항체로, 연구용으로 사용. 장기 보관 시 -20°C에서 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
- Publications: View 2 publications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
- Publications: View references
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GSPT1. Recombinant protein control fragment (Product #RP-98657) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642244 |
Product Specific Information
- Immunogen sequence:
GGAANNHGAG SGAGGRAAPV ESSQEEQSLC EGSNSAVS - Highest antigen sequence identity to orthologs:
- Mouse: 66%
- Rat: 74%
Target Information
eRF3a (eukaryotic peptide chain release factor subunit 3a), also known as GSPT1 (G1 to S phase transition 1), is a 499 amino acid protein belonging to the GTP-binding elongation factor family. It regulates cell growth by controlling translation termination.
Human eRF3a shares 94% sequence identity with its mouse counterpart, indicating conserved function. The gene encoding eRF3a maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome.
The GAN gene on chromosome 16, when mutated, may lead to giant axonal neuropathy—a nervous system disorder characterized by progressive malfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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