Thermo Fisher Scientific CD91 Monoclonal Antibody (A2MR-a2), NovaFluor Yellow 730, eBioscience

Thermo Fisher Scientific CD91 Monoclonal Antibody (A2MR-a2), NovaFluor Yellow 730, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.1 µg)/test
Publications: -

Product Specifications

Product Specific Information

The A2MR-a2 monoclonal antibody reacts with human CD91, also known as LRP-1 and alpha-2 macroglobulin receptor. CD91 is a 600 kDa, type 1 transmembrane protein consisting of alpha and beta chains. The alpha chain interacts with multiple structurally and functionally diverse ligands, while the beta chain contains tyrosine phosphorylation motifs for adaptor and signaling protein interactions.

This receptor is expressed in monocytic lineage cells, dendritic cells, hepatocytes, fibroblasts, adipocytes, neurons, and syncytiotrophoblasts. CD91 participates in antigen cross-presentation via MHC class I molecules and plays roles in cell migration and signaling activation.

Each product contains:

• 1 vial of NovaFluor conjugate
• 1 vial of CellBlox Plus Blocking Buffer

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested on normal human peripheral blood cells
Recommended usage: 5 µL (0.1 µg) per test (100 µL total volume, 10⁵–10⁸ cells/test)

NovaFluor dyes are not compatible with DNA intercalating viability dyes (e.g., propidium iodide, 7-AAD, DAPI).
Use Invitrogen LIVE/DEAD Fixable Dead Cell stains for NovaFluor dyes.

This conjugate ships with CellBlox Plus Blocking Buffer (Cat. No. C001T06F01), which improves formulation over previous CellBlox.
Add 5 µL of CellBlox Plus Blocking Buffer per sample for optimal staining.

NovaFluor conjugates utilize Phiton™ technology, based on novel nucleic acid dye structures for engineered fluorescent signatures minimizing spillover and spread impacts.

Excitation: 552 nm
Emission: 718 nm
Laser: 561 nm (Yellow)

Target Information

The protein encoded by this gene functions as an endocytic receptor involved in intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. It mediates A2M-dependent clearance of amyloid precursor protein and beta-amyloid, key components of Alzheimer’s plaques. Expression decreases with age and is reduced in Alzheimer’s brain tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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