Thermo Fisher Scientific COL22A1 Polyclonal Antibody

Applications

• Western Blot (WB): 1.0 µg/mL
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Product Specifications

Target Information

This gene encodes a member of the collagen family, contributing to the stabilization of myotendinous junctions and strengthening skeletal muscle attachments during contractile activity. It belongs to the fibril-associated collagens with interrupted triple helix (FACIT) subset, which associate with collagen fibers through their C-terminal collagenous domains and mediate protein-protein interactions through their N-terminal noncollagenous domains. The encoded protein is deposited in the basement membrane zone of the myotendinous junction, present at tissue junctions of muscles, tendons, heart, articular cartilage, and skin. Knockdown of the orthologous zebrafish gene induces muscular dystrophy by disrupting the myotendinous junction.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.