Thermo Fisher Scientific TSG Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TSG. Recombinant protein control fragment (Product #RP-90897). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TSG,uniProtId:Q9GZX9-1,ncbiNodeId:9606,antigenRange:68-217,antigenLength:223,antigenImageFileName:PA5-53248_TSG_Q9GZX9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53248_TSG_Q9GZX9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648991

Product Specific Information

Immunogen sequence: DECCDCVGMC NPRNYSDTPP TSKSTVEELH EPIPSLFRAL TEGDTQLNWN IVSFPVAEEL SHHENLVSFL ETVNQPHHQN VSVPSNNVHA PYSSDKEHMC TVVYFDDCMS IHQCKISCES MGASKYRWFH NACCECIGPE CIDYGSKTVK

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

Target Information

TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.