Thermo Fisher Scientific Tau Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 150 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: Tau.

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures.
Axonal polarity is influenced by TAU/MAPT localization within neuronal cells.
Short isoforms contribute to cytoskeletal plasticity, while longer isoforms aid stabilization.

In its hyper-phosphorylated form, Tau forms paired helical filaments (PHF), the main component of neurofibrillary tangles in Alzheimer’s disease (AD).
Hyper-phosphorylation disrupts Tau’s microtubule-binding function, leading to neuronal degeneration.
Tau phosphorylation is mediated by several kinases including GSK-3β, PKA, cdk5, and casein kinase II.
Abnormal Tau aggregation is also observed in Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.