Thermo Fisher Scientific Tau Polyclonal Antibody
Tau 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 IHC에 적합. 인간 시료에 반응하며, 동결건조 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장. 알츠하이머병 등 신경퇴행 연구에 활용 가능.
- 카탈로그번호
- OST00388W-150UL
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 2–40 of human Tau (Microtubule Associated Protein Tau) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 150 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Tau.
Target Information
Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules.
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures.
Axonal polarity is influenced by TAU/MAPT localization within neuronal cells.
Short isoforms contribute to cytoskeletal plasticity, while longer isoforms aid stabilization.
In its hyper-phosphorylated form, Tau forms paired helical filaments (PHF), the main component of neurofibrillary tangles in Alzheimer’s disease (AD).
Hyper-phosphorylation disrupts Tau’s microtubule-binding function, leading to neuronal degeneration.
Tau phosphorylation is mediated by several kinases including GSK-3β, PKA, cdk5, and casein kinase II.
Abnormal Tau aggregation is also observed in Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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