Thermo Fisher Scientific PTPRM Polyclonal Antibody
Human PTPRM 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보존됩니다. 세포 성장 및 분화 관련 신호전달 연구용으로 사용됩니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein corresponding to Human PTPRM. Recombinant protein control fragment (Product #RP-105695) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856086 |
Product Specific Information
Immunogen sequence:
STRQEMTVMV NSMDKSYAEQ GTNCDEAFSF MDTHNLNGRS VSSPSSFTMK TNTLSTSVPN SYYPDETHTM ASDTSSLVQS HTYKKREPAD VPYQTGQLHP AIRVADLLQH ITQMKCAEGY GFKEEYEVST
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This receptor-type PTP has an extracellular region, a single transmembrane region, and two tandem catalytic domains. The extracellular region contains a MAM domain, an Ig-like domain, and four fibronectin type III-like repeats.
PTPRM mediates cell-cell aggregation through homophilic interaction and can interact with scaffolding protein RACK1/GNB2L1, which may be essential for downstream signaling in response to cell-cell adhesion.
Alternative splicing results in multiple transcripts encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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