Thermo Fisher Scientific LPIN1 Monoclonal Antibody (OTI1B2), TrueMAB
LPIN1 단백질을 인식하는 Mouse monoclonal 항체로 Western blot 및 IHC(P) 검증 완료. Human 시료에 반응하며, Affinity chromatography로 정제된 액상 형태. 지방 대사 및 인슐린 감수성 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–274 of human LPIN1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2, and Lipin-3. All contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain, and a carboxy-terminal (CLIP) domain.
LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. It selectively activates a subset of PGC-1A target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation, by inducing expression of the nuclear receptor PPARA.
LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency may lead to insulin resistance and lipodystrophy — a group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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