Thermo Fisher Scientific 53BP2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 200-330 of TP53BP2 (NP_0010268552) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:53BP2,uniProtId:Q13625-1,ncbiNodeId:9606,antigenRange:200-330,antigenLength:1128,antigenImageFileName:PA5-110511_53BP2_Q13625-1_Rabbit.svg,antigenImageFileNamePDP:PA5-110511_53BP2_Q13625-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.4 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2855922

Product Specific Information

Immunogen sequence: RALKGHVEQK RLSNGKLVEE IEQMNNLFQQ KQRELVLAVS KVEELTRQLE MLKNGRIDSH HDNQSAVAEL DRLYKELQLR NKLNQEQNAK LQQQRECLNK RNSEVAVMDK RVNELRDRLW KKKAALQQKE N

Target Information

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.