Thermo Fisher Scientific PTPRS Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal PTPRS 항체. Western blot 및 IHC에 사용 가능. Affinity chromatography로 정제된 액상 형태이며, PBS/glycerol buffer에 보관. 신경 성장 및 신호 조절 관련 연구에 적합.
- 카탈로그번호
- PA5100312
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PTPRS (Accession Q13332), corresponding to amino acid residues W447–Y497 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2849826 |
Product Specific Information
Antibody detects endogenous levels of total PTPRS.
Target Information
PTPRS is a cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to these molecules has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth.
It contributes to inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, and also plays a role in stimulating neurite outgrowth in response to heparan sulfate proteoglycan GPC2.
PTPRS is required for normal brain development, especially for the pituitary gland and olfactory bulb. It functions as a tyrosine phosphatase, mediating dephosphorylation of NTRK1, NTRK2, and NTRK3, and down-regulates signaling cascades leading to activation of Akt and MAP kinases.
Additionally, it down-regulates TLR9-mediated activation of NF-kappa-B and production of TNF, interferon alpha, and interferon beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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