Thermo Fisher Scientific c-Myc Monoclonal Antibody (9 E11)

Applications and Tested Dilution

Product Specifications

Target Information

The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a central role in cellular proliferation, differentiation, apoptosis, and cell cycle progression. Phosphorylation of c-Myc at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK is associated with regulation of proliferation and the cell cycle.

c-Myc is essential for vasculogenesis and angiogenesis during tumor development. The c-myc oncogene (p62 c-myc) controls normal cellular proliferation and differentiation, and its deregulated expression induces apoptosis in different cell types. Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to either amino- or carboxy-termini of target proteins.

c-Myc, N-Myc, and L-Myc proteins function in proliferation, differentiation, and neoplastic disease. Amplification of the c-Myc gene has been found in several human tumors, including lung, breast, and colon carcinomas, while N-Myc amplification is observed in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to immunoglobulin loci on chromosomes 14, 2, or 22 is characteristic of Burkitt’s lymphoma and other B-cell lymphoproliferative disorders. Aberrant expression of c-Myc occurs in tumors of various origins such as colorectal, gastric, hepatic, mammary, ovarian, pulmonary, thyroidal, and hematopoietic neoplasms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.