Thermo Fisher Scientific LAT Polyclonal Antibody
Rabbit polyclonal antibody against LAT protein for WB and IP applications. Recognizes human LAT residues 212–262. Predicted cross-reactivity with rat and mouse. Supplied as liquid, 1 mg/mL, stored at 4°C, shipped on wet ice.
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- A305893Ax (2개 옵션)
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Applications
Western Blot (WB)
- Tested Dilution: 1:10,000–1:25,000
Immunoprecipitation (IP)
- Tested Dilution: 50–100 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 212 and 262 of human Linker for Activation of T-cells family member 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
Predicted reactivity by homology: Rat, Mouse.
Target Information
LAT (Linker for Activation of T cells) is a 36–38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells, and platelets.
After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules.
LAT is essential for TCR-dependent T cell and FcεRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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