Thermo Fisher Scientific TMP21 Polyclonal Antibody
TMP21 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. 인간, 생쥐, 랫트 반응성. Protein A 정제, 액상 형태, -20°C 보관. Alzheimer’s 관련 연구에 적합.
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Thermo Fisher Scientific TMP21 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TMP21, amino acids 101–200 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is a component of the presenilin complex and modulates the γ-secretase but not the ε-secretase cleavage activity of the amyloid precursor protein. The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave the amyloid precursor protein at γ- and ε-sites, potentially leading to the accumulation of the Abeta cleavage product associated with Alzheimer’s disease. Co-immunoprecipitation experiments indicate TMP21’s role in regulating this complex. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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