Thermo Fisher Scientific TARDBP TAR DNA binding protein/TDP43 Recombinant Rabbit Monoclonal Antibody (TARDP/9299R)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL

Product Specifications

Product Specific Information

• Positive Control: Human cerebrum or colon
• Cellular Location: Absent from the nucleus of affected neurons; primary component of cytoplasmic ubiquitin inclusions. In patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS).

Target Information

TDP43 was first identified as a cellular protein binding to HIV-1 TAR DNA sequence motifs, acting as a transcriptional repressor of the HIV-1 LTR. It also regulates splicing of exon 9 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene through association with UG repeats at the 3′ splice site.
A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 (pathologic TDP43) is the major disease protein in ubiquitin-positive, tau- and alpha-synuclein-negative frontotemporal dementia (FTLD-U). TDP43 is distinct from TRBP1, another RNA-binding protein that binds HIV-1 TAR RNA sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.