Thermo Fisher Scientific CLSTN1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CLSTN1 N-terminal region. Validated for Western blot applications. High sequence homology across multiple species. Supplied as unconjugated liquid form with 0.5 mg/mL concentration. Suitable for research use o...
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human CLSTN1 (aa 35–84) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2609951 |
Product Specific Information
Peptide sequence:
KPWLEPTYHG IVTENDNTVL LDPPLIALDK DAPLRFAESF EVTVTKEGEI
Sequence homology:
Cow: 82%
Dog: 92%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 85%
Target Information
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion by retarding intracellular APP maturation. In complex with APBA2 and C99 (a C-terminal APP fragment), CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, likely through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), probably by competing with AICD for APBB1-binding. CLSTN1 may modulate calcium-mediated postsynaptic signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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