Thermo Fisher Scientific EPS8L1 Polyclonal Antibody
Human EPS8L1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 최적화됨. 항원 친화 크로마토그래피로 정제된 액상 시약이며, 높은 종간 보존성(95~96%)을 보임. 세포 성장 및 골격 재구성 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human EPS8L1. Recombinant protein control fragment (Product #RP-99081). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641075 |
Product Specific Information
Immunogen sequence:
PKPSAKSIYE QRKRYSTVVM ADVSQYPVNH LVTFCLGEDD GVHTVEDASR KLAVMDSQGR VWAQEMLLRV SPDHVTLLDP
Sequence identity to orthologs:
- Mouse: 95%
- Rat: 96%
Target Information
Eps8L1 (EPS8-like 1), also known as DRC3 or EPS8R1, is a 723 amino acid cytoplasmic protein belonging to the Eps8 family. It is expressed in placental tissue and stimulates the guanine exchange activity of Sos1 (Son of Sevenless homolog 1), promoting Ras-bound GDP to GTP exchange.
Eps8L1 associates with Actin, contributing to membrane ruffling and cytoskeletal remodeling. Through regulation of protein activation and cytoskeleton dynamics, Eps8L1 may be involved in cell growth and differentiation. It contains one SH3 domain and is expressed as four isoforms due to alternative splicing.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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