Thermo Fisher Scientific DENND3 Polyclonal Antibody
Human DENND3 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. RAB12 활성화 및 자가포식 연구에 적합.
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- PA564996
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Thermo Fisher Scientific DENND3 Polyclonal Antibody
Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human DENND3. Recombinant protein control fragment (Product #RP-105756) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2661937 |
Product Specific Information
Immunogen sequence:
PTSFLMGCHLD HFEEVSKEAD GLVLINIDHG SITYSKSTDD NVDIPDVPLL AAQTFIQRVQ SLQLHHELHA AHLLSSTDLK EGRAHRRSWQ QKLNCQIQQT T
Highest antigen sequence identity to the following orthologs:
- Mouse: 81%
- Rat: 78%
Target Information
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701).
Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, allowing recruitment of 14-3-3 adapter proteins and up-regulating GEF activity towards RAB12.
Also involved in protein transport from recycling endosomes to lysosomes, regulating degradation of transferrin receptor and amino acid transporter PAT4 (PubMed:20937701).
Starvation induces phosphorylation at Tyr-858, which enhances GEF activity and initiates autophagy. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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