Thermo Fisher Scientific DENND3 Polyclonal Antibody
Human DENND3 단백질을 인식하는 Rabbit Polyclonal Antibody로, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. RAB12 활성화 및 자가포식 연구에 적합.
✨AI 추천 연관 상품
AI가 분석한 이 상품과 연관된 추천 상품들을 확인해보세요
연관 상품을 찾고 있습니다...
Thermo Fisher Scientific DENND3 Polyclonal Antibody
Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human DENND3. Recombinant protein control fragment (Product #RP-105756) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2661937 |
Product Specific Information
Immunogen sequence:
PTSFLMGCHLD HFEEVSKEAD GLVLINIDHG SITYSKSTDD NVDIPDVPLL AAQTFIQRVQ SLQLHHELHA AHLLSSTDLK EGRAHRRSWQ QKLNCQIQQT T
Highest antigen sequence identity to the following orthologs:
- Mouse: 81%
- Rat: 78%
Target Information
Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701).
Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, allowing recruitment of 14-3-3 adapter proteins and up-regulating GEF activity towards RAB12.
Also involved in protein transport from recycling endosomes to lysosomes, regulating degradation of transferrin receptor and amino acid transporter PAT4 (PubMed:20937701).
Starvation induces phosphorylation at Tyr-858, which enhances GEF activity and initiates autophagy. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 없음)
🏷️Thermo Fisher Scientific 상품 둘러보기
동일 브랜드의 다른 상품들을 확인해보세요
Thermo Fisher Scientific
Thermo Fisher Scientific DNAJC8 Polyclonal Antibody
791,800원
Thermo Fisher Scientific
Thermo Fisher Scientific RP1L1 Polyclonal Antibody
791,800원
Thermo Fisher Scientific
Thermo Fisher Scientific DENND3 Polyclonal Antibody
791,800원
Thermo Fisher Scientific
Thermo Fisher Scientific DSCC1 Polyclonal Antibody
791,800원
Thermo Fisher Scientific
Thermo Fisher Scientific MAD2L2 Polyclonal Antibody
791,800원
배송/결제/교환/반품 안내
배송 정보
| 기본 배송비 |
| 교환/반품 배송비 |
|
|---|---|---|---|
| 착불 배송비 |
| ||
| 교환/반품 배송비 |
| ||
결제 및 환불 안내
| 결제수단 |
|
|---|---|
| 취소 |
|
| 반품 |
|
| 환급 |
|
교환 및 반품 접수
| 교환 및 반품 접수 기한 |
|
|---|---|
| 교환 및 반품 접수가 가능한 경우 |
|
| 교환 및 반품 접수가 불가능한 경우 |
|
교환 및 반품 신청
| 교환 절차 |
|
|---|---|
| 반품 절차 |
|