Thermo Fisher Scientific PICK1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human PICK1 단백질로, ICC/IF 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 완충액에 보관됩니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PICK1 Polyclonal Antibody
Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
- Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PICK1. Recombinant protein control fragment (Product #RP-107567) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2664903 |
Product Specific Information
Immunogen sequence:
LTIKKYLDVKF EYLSYCLKVK EMDDEEYSCI ALGEPLYRVS TGNYEYRLIL RCRQEARARF SQMRKDVLEK MELLD
- Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization.
The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain.
Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCα), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain.
The interaction of PICK1 with PKCα is highly dependent on the activation of the kinase. PICK1 directs the activated form of PKCα to membrane-anchored GluR2. Once phosphorylated by PKCα, GluR2 is released from the synaptic anchor proteins and transported from the synaptic membrane in a PICK1-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.