Thermo Fisher Scientific DCLK1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human DCLK1 (DCAMKL1). Validated for IHC (Paraffin) at 1:50–1:200 dilution. Affinity purified, liquid form, unconjugated. Supplied in PBS with glycerol and sodium azide. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DCAMKL1 (amino acids 311–422) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at −20°C and avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640414 |
Product Specific Information
Immunogen sequence:
TSSVNGTPGS QLSTPRSGKS PSPSPTSPGS LRKQRSSQHG GSSTSLASTK VCSSMDENDG PGEEVSEEGF QIPATITERY KVGRTIGDGN FAVVKECVER STAREYALKI IK
Highest antigen sequence identity to orthologs:
- Mouse: 96%
- Rat: 96%
Target Information
DCAMKL1 (DCLK1), also known as doublecortin-like kinase 1, is a serine/threonine kinase containing:
- Two N-terminal doublecortin domains (bind microtubules and regulate polymerization)
- A C-terminal serine/threonine protein kinase domain (homologous to Ca²⁺/calmodulin-dependent kinase)
- A serine/proline-rich domain mediating multiple protein-protein interactions
DCAMKL1 is a microtubule-associated kinase capable of autophosphorylation and microtubule polymerization independent of its kinase activity. It plays roles in neuronal migration, retrograde transport, apoptosis, and neurogenesis.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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