Thermo Fisher Scientific SRD5A1 Polyclonal Antibody
SRD5A1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ELISA 등 다양한 응용에 적합합니다. 인간, 생쥐, 소, 양, 랫드에서 반응하며, Protein A로 정제된 고순도 항체입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific SRD5A1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Sheep, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human SRD5A1, amino acids 101–200 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Steroid 5α-Reductase is an important enzyme in androgen physiology that catalyzes the conversion of testosterone into the more potent 5α-dihydrotestosterone, which mediates androgen effects on target tissues.
The enzyme exists as two isoforms:
- Type 1: Expressed mainly in the skin
- Type 2: Expressed mainly in the prostate
In cultured human skin cells, 5α-Reductase 1 shows heterogeneity of protein and varying levels of transcriptional and translational expression. It is expressed in all portions of the hair follicle, whereas 5α-Reductase 2 is expressed only in mesenchymal portions.
5α-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of 5α-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent breast carcinoma.
The 5α-Reductase–3α-hydroxysteroid dehydrogenase complex is also present in the human brain, suggesting involvement in the synthesis of neuroactive steroids or catabolism of neurotoxic steroids.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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