Thermo Fisher Scientific PICALM/CALM Polyclonal Antibody
PICALM/CALM 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 사용 가능. Human과 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 602 to 652 of Human Phosphatidylinositol-binding clathrin assembly protein (CALM) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and Golgi area. It is an important component of the coated pit internalization machinery.
Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia.
PICALM is also expressed in neurons and is present at the synapse, facilitating endocytosis of the synaptic vesicle protein VAMP2.
Recent studies have identified PICALM variants associated with Alzheimer’s disease, suggesting a role in endocytosis and recycling of amyloid protein precursor (APP).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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