Thermo Fisher Scientific SARS-CoV-2 NSP1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Store as concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.

Target Information

SARS-CoV-2 nsp1 inhibits host translation by interacting with the 40S ribosomal subunit (PubMed:32680882).
The nsp1 C-terminus binds to and obstructs the ribosomal mRNA entry tunnel, thereby inhibiting antiviral responses triggered by innate immunity or interferons.
The nsp1-40S ribosome complex induces endonucleolytic cleavage near the 5′UTR of host mRNAs, leading to their degradation.
Viral mRNAs are protected from nsp1-mediated cleavage due to the presence of a 5′-end leader sequence.
By suppressing host gene expression, nsp1 facilitates efficient viral gene expression and immune evasion in infected cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.