Thermo Fisher Scientific SARS-CoV-2 NSP1 Polyclonal Antibody
SARS-CoV-2 nsp1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용.
- 카탈로그번호
- PA5119598
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- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of SARS-CoV-2 (COVID-19) nsp1 (Strain: Wuhan-Hu-1). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913171 |
Product Specific Information
Store as concentrated solution. Centrifuge briefly prior to opening vial.
For short-term storage (1–2 weeks), store at 4°C.
For long-term storage, aliquot and store at -20°C or below.
Avoid multiple freeze-thaw cycles.
Target Information
SARS-CoV-2 nsp1 inhibits host translation by interacting with the 40S ribosomal subunit (PubMed:32680882).
The nsp1 C-terminus binds to and obstructs the ribosomal mRNA entry tunnel, thereby inhibiting antiviral responses triggered by innate immunity or interferons.
The nsp1-40S ribosome complex induces endonucleolytic cleavage near the 5′UTR of host mRNAs, leading to their degradation.
Viral mRNAs are protected from nsp1-mediated cleavage due to the presence of a 5′-end leader sequence.
By suppressing host gene expression, nsp1 facilitates efficient viral gene expression and immune evasion in infected cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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