Thermo Fisher Scientific MEMO1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
AMESHKDEFT IIPVLVGALS ESKEQEFGKL FSKYLADPSN LFVVSSDFCH

• For short term use, store at 2–8°C up to 1 week.
• For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Target Information

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling.
The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex.
It controls the localization of APC and CLASP2 to the cell membrane, via regulation of GSK3B activity.
Membrane-bound APC allows localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Is required for breast carcinoma cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.