Thermo Fisher Scientific RGL1 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RGL1 (NP_055964.3, 1 a.a. approximately 803 a.a) full-length human protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MEVKPVGEPT QEVSKFKLST KVESTGHWLV EDHVRIWEVL KTEESSIQDW GEEVEEGAVY HVTLKRVQIQ QAANKGARWL GVEGDQLPPG HTVSQYETCK IRTIKAGTLE KLVENLLTAF GDNDFTYISI FLSTYRGFAS TKEVLELLLD RYGNLTSPNC EEDGSQSSSE SKMVIRNAIA SILRAWLDQC AEDFREPPHF PCLQKLLDYL TRMMPGSDPE RRAQNLLEQF QKQEVETDNG LPNTISFSLE EEEELEGGES AEFTCFSEDL VAEQLTYMDA QLFKKVVPHH CLGCIWSRRD KKENKHLAPT IRATISQFNT LTKCVVSTIL GGKELKTQQR AKIIEKWINI AHECRLLKNF SSLRAIVSAL QSNSIYRLKK TWAAVPRDRM LMFEELSDIF SDHNNHLTSR ELLMKEGTSK FANLDSSVKE NQKRTQRRLQ LQKDMGVMQG TVPYLGTFLT DLTMLDTALQ DYIEGGLINF EKRRREFEVI AQIKLLQSAC NSYCMTPDQK FIQWFQRQQL LTEEESYALS CEIEAAADAS TTSPKPRKSM VKRLSLLFLG SDMITSPTPT KEQPKSTASG SSGESMDSVS VSSCESNHSE AEEGSITPMD TPDEPQKKLS ESSSSCSSIH SMDTNSSGMS SLINPLSSPP SCNNNPKIHK RSVSVTSITS TVLPPVYNQQ NEDTCIIRIS VEDNNGNMYK SIMLTSQDKT PAVIQRAMLK HNLDSDPAEE YELVQVISED KELVIPDSAN VFYAMNSQVN FDFILRKKNS MEEQVKLRSR TSLTLPRTAK RGCWSNRHSK ITL

Target Information

Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation. RGL1 (ral guanine nucleotide dissociation stimulator-like 1), also known as RGL or RalGDS-like 1, is a 768 amino acid protein that is a putative GEF. Strongly expressed in brain, heart, spleen, kidney and testis, RGL1 is a downstream effector protein that is involved in Ras and Ral signaling pathways. RGL1 contains an N-terminal Ras-GEF domain and a C-terminal Ras-interacting domain that interacts with the GTP-bound form of Ras through its effector loop. Due to its similarity to Ral GDS, RGL1 may be implicated in carcinogenesis. Two isoforms exist due to alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.