Thermo Fisher Scientific RAB8A Recombinant Rabbit Monoclonal Antibody (JE64-79)

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Target Information

The protein encoded by this gene is a member of the RAS superfamily of small GTP/GDP-binding proteins with an average size of 200 amino acids.
RAB/YPT family proteins may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and plasma membrane.
This protein shares 97%, 96%, and 51% similarity with dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively, and contains four GTP/GDP-binding sites common to RAS proteins.
It also includes a C-terminal CAAX motif characteristic of RAS superfamily members but absent in most RAB proteins.
Although isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrated.
This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.