Thermo Fisher Scientific PLA2R1 Polyclonal Antibody
PLA2R1 단백질을 인식하는 염소 유래 폴리클로날 항체로, Western blot 및 유세포분석에 사용 가능. 인간에 반응하며 개 및 돼지에서 예측 반응. 고순도 액상 형태로 제공되며, 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (EKKKDTPKQHGT) corresponding to internal amino acids of PLA2R1 (aa 946–958) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_11004391 |
Product Specific Information
- Predicted to react with canine and porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:1,000.
Target Information
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also binds to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the MAPK cascade to induce cell proliferation, production of lipid mediators, and selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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