ELK Biotechnology IGF-I Receptor β (phospho-Tyr980) rabbit pAb
IGF-I Receptor β (phospho-Tyr980) rabbit polyclonal antibody로, 인슐린 유사 성장인자 수용체의 인산화 상태를 검출. WB에 적합하며 Human, Mouse, Rat 시료 반응. 세포막 단일 통과형 단백질 표적, 암세포 생존 연구에 활용 가능.
- 판매단위
- pk
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제품명
IGF-I Receptor β (phospho-Tyr980) rabbit pAb
대체 명칭
Insulin-like growth factor 1 receptor (EC 2.7.10.1), Insulin-like growth factor I receptor, IGF-I receptor, CD antigen CD221
Cleaved into:
- Insulin-like growth factor 1 receptor alpha chain
- Insulin-like growth factor 1 receptor beta chain
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human IGF-I Receptor β (Tyr980) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | pro: 155 kD, receptor beta: 95 kD |
| GeneID (Human) | 3480 |
| Human Swiss-Prot No | P08069 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human, Mouse, Rat |
배경 (Background)
This receptor binds insulin-like growth factor with high affinity and possesses tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues, functioning as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
[Provided by RefSeq, May 2014]
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