ELK Biotechnology IMPA1 rabbit pAb

ELK Biotechnology IMPA1 rabbit pAb

제품 설명

IMPA1 rabbit pAb는 인간 IMPA1 단백질을 인식하는 토끼 폴리클로날 항체입니다.
이 효소는 myo-inositol monophosphate를 탈인산화하여 세포 내 신호전달에 중요한 myo-inositol을 생성합니다.
리튬에 의해 억제되는 magnesium 의존성 인산분해효소로, 조울증 치료제의 작용기전 연구에 활용됩니다.

제품 정보

Background

This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myo-inositol 1,4,5-trisphosphate and diacylglycerol.
This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2’-AMP as substrates.
It shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium.
Inhibition of inositol monophosphate hydrolysis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium used to treat bipolar disorder.
Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [RefSeq, Dec 2014]