ELK Biotechnology Met (phospho-Tyr1234/1235) rabbit pAb
Met 단백질의 Tyr1234/1235 인산화 상태를 검출하는 rabbit polyclonal antibody로, WB, ELISA, IHC에 적합합니다. 인간, 마우스, 랫트에서 반응하며 세포막 단백질 분석에 유용합니다. 고순도 IgG, 1 mg/ml 농도로 제공됩니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Met (phospho-Tyr1234/1235) rabbit pAb
제품명
Met (phospho-Tyr1234/1235) rabbit pAb
공급업체
ELK Biotechnology
제품 개요
Met 단백질의 Tyr1234 및 Tyr1235 부위 인산화 상태를 특이적으로 인식하는 rabbit polyclonal antibody입니다. 세포 내 신호전달 및 암 관련 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Hepatocyte growth factor receptor (HGF receptor), HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 2000–20000 |
| Immunogen | Synthesized phospho peptide around human Met (Tyr1234 and 1235) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 145 kD |
| GeneID (Human) | 4233 |
| Human Swiss-Prot No | P08581 |
| Cellular Localization | Membrane; Single-pass type I membrane protein. [Isoform 3]: Secreted. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the receptor tyrosine kinase family of proteins and is the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which reduces lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, playing roles in cellular survival, embryogenesis, migration, and invasion. Mutations are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression are linked to multiple human cancers.
(provided by RefSeq, May 2016)
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.