Thermo Fisher Scientific CytoScan XON Assay Kit

Applied Biosystems™ CytoScan™ XON Assay Kit

The Applied Biosystems CytoScan XON Suite is an exon-level copy number solution that provides the sensitivity and flexibility required to improve and complement the analysis of important variants for clinical research. It is designed to cover the whole genome, with an increased focus on 7,000 clinically relevant genes.

The CytoScan XON Suite is a full solution comprised of the assay, array, and analysis software. This CytoScan XON Assay Kit contains arrays and reagents sufficient for 24 reactions.
Customer training is required for the CytoScan XON Assay.
Different training programs are available based upon your experience level. Please contact your local distributor for details.

Sensitive exon-level copy number and superior coverage across the whole genome

Comprehensive and effective detection of deletions and duplications can be challenging from a cost perspective when using multiplex ligation-dependent probe amplification (MLPA) assays or exome arrays for medical research.
The CytoScan XON Suite is a microarray solution that detects single-exon deletion and duplication events with high sensitivity in key relevant genes, in addition to providing whole-genome coverage.
The single-nucleotide polymorphism (SNP) probes allow sample tracking, duo/trio, and loss of heterozygosity (LOH) analysis.

Smart design improves resolution in key genes

The CytoScan XON Array content was designed through empirical selection from a pool of over 49 million probes for copy number responses across the genome. The best performing probes were selected to cover key genes and the exons within them.
Any gaps were filled with additional probes flanking 500 bp from the targeted region, ensuring that each exon contains enough probes to make a reliable call.

Reporting flexibility with gene panel or gene-level tier analysis

The Chromosome Analysis Suite (ChAS) software enables flexible viewing and summarizing of exon-level CNV results based on specific clinical research needs.

Gene panel analysis

Simplify result reporting by using your preferred gene list or panel in the intuitive ChAS software. This feature allows you to obtain exon-level CNV results limited to the gene panel you upload and view only the genes of interest.

Gene-level tier analysis

Gene-level tier analysis in ChAS software provides a novel approach where results are organized by gene-level tiers based on clinical research relevance.
This functionality allows visualization of CNVs for a targeted number of clinically relevant genes (level 1) or expands tiers for a whole-genome view.
Users can determine the gene-level tiers of interest for analysis and reporting.

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