ELK Biotechnology Myosin IIa (phospho-Ser628) rabbit pAb
Myosin IIa (phospho-Ser628) rabbit polyclonal antibody for WB and IHC applications. Targets phosphorylated Myosin-9 involved in cytoskeleton and cell motility. High specificity and stability with -20°C storage up to 1 year. Suitable for human, mouse, a...
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Myosin IIa (phospho-Ser628) rabbit pAb
제품 개요
ELK Biotechnology의 Myosin IIa (phospho-Ser628) rabbit polyclonal antibody는 인산화된 Myosin IIa 단백질(Ser628)을 인식하도록 제작된 항체로, 세포골격 및 세포 이동 관련 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Myosin IIa (phospho-Ser628) rabbit pAb |
| Alternative Names | Myosin-9 (Cellular myosin heavy chain, type A), Myosin heavy chain 9, Non-muscle myosin heavy chain A (NMMHC-A), Non-muscle myosin heavy chain IIa (NMMHC II-a), NMMHC-IIA |
| Applications | WB; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300 |
| Immunogen | Synthesized phospho peptide around human Myosin IIa (Ser1943) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 215 kD |
| GeneID (Human) | 4627 |
| Human Swiss-Prot No | P35579 |
| Cellular Localization | Cytoplasm, cytoskeleton; cell cortex; cytoplasmic vesicle (secretory vesicle, cortical granule). Colocalizes with actin filaments at lamellipodia margins and leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, localized to stress fiber-like structures and cytoplasmic puncta (PubMed:27331610). |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a conventional non-muscle myosin. The encoded protein, Myosin IIA heavy chain, contains an IQ domain and a myosin head-like domain involved in cytokinesis, cell motility, and maintenance of cell shape. Mutations are associated with non-syndromic sensorineural deafness (autosomal dominant type 17), Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome, and macrothrombocytopenia with progressive sensorineural deafness. [RefSeq, Dec 2011]
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