ELK Biotechnology MYPT1 (phospho-Ser668) rabbit pAb
MYPT1 (phospho-Ser668) rabbit polyclonal antibody로, 인산화된 MYPT1 단백질 검출에 적합합니다. WB, ELISA, IHC에 사용 가능하며, 사람, 쥐, 생쥐에 반응합니다. 세포질 및 세포골격 위치 단백질 연구에 유용합니다.
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MYPT1 (phospho-Ser668) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1), Myosin phosphatase target subunit 1, Protein phosphatase myosin-binding subunit |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized phospho peptide around human MYPT1 (Ser668) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kDa |
| Gene ID (Human) | 4659 |
| Human Swiss-Prot No. | O14974 |
| Cellular Localization | Cytoplasm; Cytoplasm, cytoskeleton, stress fiber; also along actomyosin filaments |
| Species Reactivity | Human; Rat; Mouse |
Background
Myosin phosphatase target subunit 1 (MYPT1), also known as the myosin-binding subunit of myosin phosphatase, is a regulatory component of myosin phosphatase. This enzyme modulates the interaction between actin and myosin downstream of the small GTPase Rho. RhoA, in its active GTP-bound form (GTP·RhoA), interacts with the myosin-binding subunit (MBS) of myosin phosphatase, influencing the phosphorylation state of myosin light chain (MLC). Activation of Rho-associated kinase (Rho-kinase) by GTP·RhoA leads to phosphorylation and inactivation of myosin phosphatase, thereby regulating smooth muscle contraction and cytoskeletal dynamics in nonmuscle cells.
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