ELK Biotechnology NEC1 rabbit pAb

제품명

NEC1 rabbit pAb

공급업체

ELK Biotechnology

제품 설명

NEC1 rabbit pAb는 인간 NEC1 단백질(AA 125-175)에서 유래한 합성 펩타이드로 면역하여 제작된 다클론 항체입니다. 세포 내 분비 소낭 및 분비 과립에 위치하며, 단백질 및 펩타이드 전구체의 프로세싱과 관련된 연구에 사용됩니다.

제품 스펙

Background

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic event takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene (provided by RefSeq, Jan 2014).