ELK Biotechnology NISCH rabbit pAb

제품명

NISCH rabbit pAb

제품 개요

ELK Biotechnology에서 제공하는 NISCH rabbit pAb는 인간 NISCH 단백질을 인식하는 폴리클로날 항체입니다. 세포막, 세포질 및 다양한 엔도솜 구조에서 발현되는 단백질 연구에 적합합니다.

제품 스펙

세포 내 위치

Cell membrane, cytoplasm, early endosome, recycling endosome.
Enriched in early/sorting and recycling endosomes.
Colocalized in early/sorting endosomes with EEA1 and SNX2, and in recycling endosomes with transferrin receptor.
Detected in the perinuclear region partially associated with punctate structures.
Colocalizes with PAK1, RAC1, MAPK1, and MAPK3 in various cellular regions.
(By similarity)

배경 정보

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane.
The orthologous mouse protein influences cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin.
In humans, it binds to insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes.
Expression is reduced in human breast cancers, while overexpression reduces tumor growth and metastasis, possibly by limiting alpha-5 integrin expression.
In cardiac tissue, it affects cell growth and death; in neural tissue, it influences neuronal growth and differentiation.
Alternative splicing results in multiple transcript variants encoding different isoforms, some lacking expected C-terminal domains of a functional imidazoline receptor.
(Provided by RefSeq, Jan 2013)