Thermo Fisher Scientific VISTA Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: TWYRSSRGEV QTCSERRPIR NLTFQDLHLH HGGHQAANTS HDLAQRHGLE
• Sequence homology: Cow 85%; Dog 86%; Horse 92%; Human 100%

Target Information

VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1, it has a distinct expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells, with the highest densities on myeloid cells and lower levels on T cells. It is usually absent on B cells.

VISTA expressed by antigen-presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a promising target for cancer immunotherapy. Reported ligands include CD28H, VSIG-3, and VSIG-8.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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