Thermo Fisher Scientific VISTA Polyclonal Antibody
VISTA 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합. Human 시료에 반응하며, Affinity Chromatography로 정제됨. PBS/sucrose buffer에 보관되고 -20°C에서 안정적. 면역학 및 암 연구용으로 활용 가능.
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Applications
- Western Blot (WB): 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human C10orf54 (aa 71–120) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2577273 |
Product Specific Information
- Peptide sequence: TWYRSSRGEV QTCSERRPIR NLTFQDLHLH HGGHQAANTS HDLAQRHGLE
- Sequence homology: Cow 85%; Dog 86%; Horse 92%; Human 100%
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1, it has a distinct expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells, with the highest densities on myeloid cells and lower levels on T cells. It is usually absent on B cells.
VISTA expressed by antigen-presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a promising target for cancer immunotherapy. Reported ligands include CD28H, VSIG-3, and VSIG-8.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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