Thermo Fisher Scientific Beclin 1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Rat and Orangutan

Target Information

Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate.
Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways:

• PI3KC3-C1 is involved in the initiation of autophagosomes
• PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis
  Beclin 1 also contributes to antiviral host defense.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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